IEEE UK and Ireland Circuits and Systems Chapter Seminar | Microfluidic Dielectric Biosensors for Point-of-Care Assessment of Hemostasis: From Conceptualisation to Clinical Translation
Point-of-care (POC) diagnostic devices hold great promise to significantly impact healthcare delivery and address health disparities. These devices enable a shift in focus away from the utilisation of high-cost specialised care for the treatment of late-stage diseases toward predictive, preventative, participatory, and personalised healthcare for more effective disease monitoring and management.
In this seminar, work on ClotChip® – a microfluidic sensor that utilises dielectric spectroscopy for POC assessment of blood coagulation disorders with <10 µL of whole blood will be presented. Specifically, a simple circuit model that accurately captures the frequency-dependent dielectric behaviour of human whole blood placed within a microfluidic channel will be analysed. Temporal variation in the dielectric properties of a coagulating blood sample at 1 MHz provides information about cellular (ie platelet) and non-cellular (ie coagulation factor) abnormalities in clot formation will be discussed, as well as the fibrinolytic system that regulates clot resolution to prevent thrombotic occlusions.
Finally, to establish the utility of ClotChip® as a platform technology for POC assessment of haemostasis, results from pilot clinical studies with ClotChip® on monitoring anticoagulation therapy with direct oral anticoagulants (DOACs) – a new class of FDA-approved blood thinners – as well as coagulation factor replacement therapy in haemophilia care management will be shared. Results from correlative studies between ClotChip® and clinically relevant global haemostatic assays such as rotational thromboelastometry (ROTEM) are also provided.
About the Speaker
Pedram Mohseni is the Goodrich Professor of Engineering Innovation and Inaugural Chair of the Electrical, Computer, and Systems Engineering Department at Case Western Reserve University, Cleveland, OH, USA.
He received the B.S. degree from the Sharif University of Technology, Tehran, Iran, in 1996, and the M.S. and PhD degrees from the University of Michigan, Ann Arbor, MI, USA, in 1999 and 2005, respectively, all in electrical engineering. His main research interests are in analog/mixed-signal/RF integrated bioelectronics, wireless power/data tranfer to biomedical implants, translational microfluidics, and microassays for point-of-care/point-of-injury diagnostics.
His research activities have resulted in 2 book chapters, over 155 refereed publications, and 15 issued U.S. and international patents. He was the General co-Chair of the 2018 IEEE Biomedical Circuits and Systems (BioCAS) conference and will serve again as the General co-Chair of the conference in 2025. He currently serves as the Editor-in-Chief of the IEEE Transactions on Biomedical Circuits and Systems (TBioCAS).
Dr Mohseni was inducted into the U.S. National Academy of Inventors (NAI) in 2023 as a Senior Member for producing biomedical technologies that bring real impact on the welfare of society.